Barnstable, Cape Cod's biggest town, has eight villages which each retain a different flavor and landscape which fits that flavor. The historic north side along Route 6A closely resembles many Outer Cape towns for visitors wishing to stay close to nature while being near mainland access.

Centerville, located on the south side, is primarily residential and has beautiful Craigville Beach. Osterville, also on the same side has many inlets and harbors for marine activities. Hyannis is the town's business and commercial center. It features numerous restaurants and shopping malls.

Hyannis Harbor provides steamship access to both Martha's Vineyard and Nantucket. Marstons Mills, situated along Route 28, is primarily residential. Cotuit, located on a south-side peninsula, offers some smaller beaches. West Barnstable on the north side is smaller and retains a more village-type feel. Barnstable, also on the 6A side, hosts the county court complex and features a small harbor and several beaches.